Excessive ER stress and the resulting autophagic flux dysfunction contribute to fluoride-induced neurotoxicity
Abstract
Fluoride is capable of inducing neurotoxicity, but its mechanisms remain elusive. This study aimed to explore the roles of endoplasmic reticulum (ER) stress and autophagy in sodium fluoride (NaF)-induced neurotoxicity, focusing on the regulating role of ER stress in autophagy. The in vivo results demonstrated that NaF exposure impaired the learning and memory capabilities of rats, and resulted in histological and ultrastructural abnormalities in...
Paper Details
Title
Excessive ER stress and the resulting autophagic flux dysfunction contribute to fluoride-induced neurotoxicity
Published Date
Feb 1, 2018
Journal
Volume
233
Pages
889 - 899
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