The BCL-2 arbiters of apoptosis and their growing role as cancer targets
Abstract
Impaired apoptosis plays a central role in cancer development and limits the efficacy of conventional cytotoxic therapies. Deepening understanding of how opposing factions of the BCL-2 protein family switch on apoptosis and of their structures has driven development of a new class of cancer drugs that targets various pro-survival members by mimicking their natural inhibitors, the BH3-only proteins. These 'BH3 mimetic' drugs seem destined to...
Paper Details
Title
The BCL-2 arbiters of apoptosis and their growing role as cancer targets
Published Date
Nov 3, 2017
Journal
Volume
25
Issue
1
Pages
27 - 36
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