Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP
Abstract
Cholesterol homeostasis is maintained through concerted action of the SREBPs and LXRs. Here, we report that RNF145, a previously uncharacterized ER membrane ubiquitin ligase, participates in crosstalk between these critical signaling pathways. RNF145 expression is induced in response to LXR activation and high-cholesterol diet feeding. Transduction of RNF145 into mouse liver inhibits the expression of genes involved in cholesterol biosynthesis...
Paper Details
Title
Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP
Published Date
Oct 25, 2017
Journal
Volume
6
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