Protective effects of gallic acid against methotrexate-induced toxicity in rats
Abstract
Methotrexate, as a chemotherapy drug, can cause chronic liver damage and oxidative stress. Aim of this study was to evaluate the preventive effect of gallic acid (GA) on methotrexate (MTX)-induced oxidative stress in rat liver.Twenty-eight male rats were randomly divided into four groups as control, MTX (20 mg/kg, i.p.), MTX + GA (30 mg/kg/day, orally) and GA treated. Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline...
Paper Details
Title
Protective effects of gallic acid against methotrexate-induced toxicity in rats
Published Date
Oct 25, 2017
Journal
Volume
118
Issue
3
Pages
152 - 160
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