BROMO-PROTOPINE, A NOVEL DERIVATIVE OF PROTOPINE WITH IMPROVED BIOAVAILABILITY AND BIOACTIVITY, DEGRADES TAU AGGREGATION THROUGH MODULATION OF HDAC6-HSP90 CHAPERONIC ACTIVITY AND IMPROVES MEMORY VIA STIMULATION OF THE RAS-GRF1/ERK PATHWAY
Volume: 13, Issue: 7S_Part_32
Published: Jul 1, 2017
Abstract
Recently, we identified protopine (PRO) as a novel HDAC6 inhibitor with anti-Tau activity from the Chinese medicinal herb Corydalis yanhusuo (Durairajan et. al., 2015, Neurodegenerative disease, 15 [Suppl. 1]; p1579). In this study, we investigated the mechanism of HDAC6-Hsp90 modulation by PRO and explored whether derivatization of PRO could improve its in vivo efficacy. To optimize the anti-Alzheimer's disease (AD) activity of PRO, we...
Paper Details
Title
BROMO-PROTOPINE, A NOVEL DERIVATIVE OF PROTOPINE WITH IMPROVED BIOAVAILABILITY AND BIOACTIVITY, DEGRADES TAU AGGREGATION THROUGH MODULATION OF HDAC6-HSP90 CHAPERONIC ACTIVITY AND IMPROVES MEMORY VIA STIMULATION OF THE RAS-GRF1/ERK PATHWAY
Published Date
Jul 1, 2017
Volume
13
Issue
7S_Part_32
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