Hepatitis C virus p7 induces mitochondrial depolarization of isolated liver mitochondria
Abstract
Hepatitis C virus (HCV)‑encoded protein p7 is a viroporin that acts as an ion channel and is indispensable for HCV particle production. Although the main target of HCV p7 is the endoplasmic reticulum, it also targets mitochondria. HCV‑infected cells show mitochondrial depolarization and ATP depletion; however, the function of HCV p7 in mitochondria is not fully understood. The present study demonstrated that treatment of isolated mouse liver...
Paper Details
Title
Hepatitis C virus p7 induces mitochondrial depolarization of isolated liver mitochondria
Published Date
Oct 17, 2017
Journal
Volume
16
Issue
6
Pages
9533 - 9538
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