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Newly designed organotin(IV) carboxylates with peptide linkage: Synthesis, structural elucidation, physicochemical characterizations and pharmacological investigations

Published on Jan 1, 2018in European Journal of Medicinal Chemistry4.83
· DOI :10.1016/j.ejmech.2017.11.001
Muhammad Sirajuddin13
Estimated H-index: 13
(University of Science and Technology),
Vickie McKee34
Estimated H-index: 34
(DCU: Dublin City University)
+ 1 AuthorsSaqib Ali29
Estimated H-index: 29
(QAU: Quaid-i-Azam University)
Abstract
Abstract Fourteen new organotin(IV) carboxylate complexes with peptide linkage of (2-(4-methoxy-2-nitrophenylcarbamoyl)benzoic acid) were successfully synthesized and characterized by elemental analyses, FT-IR, NMR ( 1 H, 13 C and 119 Sn) and single crystal X-ray techniques. FT-IR results of the sodium salt of 2-(4-methoxy-2-nitrophenylcarbamoyl)benzoic acid and complexes showed that the coordination took place via oxygen atoms of the carboxylate group. 1 J ( 119 Sn- 13 C), 2 J ( 119 Sn- 1 H) and θ values calculated from 1 H and 13 C NMR data using Lockhart's equation reveal a trigonal bipyramidal geometry for triorganotin(IV) derivatives and an octahedral geometry for diorganotin(IV) derivatives. Crystallographic data for three triorganotin(IV) complexes ( 1 – 3 ) showed the tin has distorted trigonal bipyramidal geometry. In vitro anticancer activity against lung carcinoma (H-157) and kidney fibroblast (BHK-21) cell lines as well as antileishmanial activity against the promastigote forms of leishmania major of the synthesized compounds were also studied and the complexes were found biologically active. The in vitro antibacterial activity of most of the synthesized organotin(IV) derivatives against the studied bacterial pathogens is higher than those of the standard 3rd generation antibiotics such as Tetracycline, Penicillin G, Ampicillin, Amoxicillin. This suggest the use of these newly designed organotin(IV) derivatives as potent antibiotics. The synthesized compounds interact with DNA via intercalative mode of interaction. Viscosity measurement results also support the intercalative mode of interaction for the compounds with DNA.
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  • Citations (13)
References51
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#1Ceyda Acilan (TÜBİTAK Marmara Research Center)H-Index: 10
#2Buse Cevatemre (Uludağ University)H-Index: 8
Last.João Costa Pessoa (IST: Instituto Superior Técnico)H-Index: 35
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Cited By13
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