Bulb extracts of Boophone disticha induce hepatotoxicity by perturbing growth, without significantly impacting cellular viability

Traditional remedies remain a prominent form of therapy in developing countries, such as South Africa. Boophone disticha, or the poison bulb, is used for the treatments of wounds. There is generally a lack of scientific evidence to support its safety or use. As hepatotoxicity is a major contributor to morbidity and mortality, and a leading factor in drug attrition during development, more emphasis should be placed on pre-clinical evaluation...