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Protease activity as a prognostic factor for wound healing in venous leg ulcers

Published on Oct 30, 2017in Cochrane Database of Systematic Reviews 6.75
· DOI :10.1002/14651858.CD012841
Maggie J Westby4
Estimated H-index: 4
,
Jo C Dumville36
Estimated H-index: 36
+ 4 AuthorsRichard D Riley37
Estimated H-index: 37
(Keele University)
Abstract
This is a protocol for a Cochrane Review (Prognosis). The objectives are as follows: To determine whether protease activity is an independent prognostic factor for the healing of venous leg ulcers.
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  • Citations (1)
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References201
Newest
Published on Mar 1, 2018in Research Synthesis Methods 3.22
Thomas P. A. Debray19
Estimated H-index: 19
(Utrecht University),
Karel G. M. Moons77
Estimated H-index: 77
(Utrecht University),
Richard D Riley37
Estimated H-index: 37
(Keele University)
Small-study effects are a common threat in systematic reviews and may indicate publication bias. Their existence is often verified by visual inspection of the funnel plot. Formal tests to assess the presence of funnel plot asymmetry typically estimate the association between the reported effect size and their standard error, the total sample size or the inverse of the total sample size. In this paper, we demonstrate that the application of these tests may be less appropriate in meta-analysis of ...
5 Citations Source Cite
Published on Aug 1, 2017in Wound Repair and Regeneration 2.95
Jodi C. McDaniel6
Estimated H-index: 6
(Ohio State University),
Laura A. Szalacha30
Estimated H-index: 30
+ 3 AuthorsNarasimham L. Parinandi35
Estimated H-index: 35
(Ohio State University)
Sustained high levels of activated polymorphonuclear leukocytes (PMNs) and PMN-derived proteases in the microenvironment of chronic venous leg ulcers (CVLUs) are linked to chronic inflammation and delayed healing. Uncontrolled PMN activity eventually destroys newly developed tissue and degrades critical growth factors. The bioactive components of fish oil (n-3 eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]) have strong inflammation-resolving actions and have been shown to assuage PMN...
1 Citations Source Cite
Published on May 1, 2017in Journal of Tissue Viability 1.93
Rosa M. Salgado4
Estimated H-index: 4
,
Otilia Cruz-Castañeda1
Estimated H-index: 1
+ 5 AuthorsEdgar Krötzsch4
Estimated H-index: 4
Abstract It has been reported that carbohydrates confer physicochemical properties to the wound environment that improves tissue repair. We evaluated in vitro and in vivo wound healing during maltodextrin/ascorbic acid treatment. In a fibroblast monolayer scratch assay, we demonstrated that maltodextrin/ascorbic acid stimulated monolayer repair by increasing collagen turnover coordinately with TGF-β1 expression (rising TGF-β1 and MMP-1 expression, as well as gelatinase activity, while TIMP-1 was...
7 Citations Source Cite
Published on Feb 1, 2017in International Wound Journal 2.38
Raffaele Serra22
Estimated H-index: 22
,
Luca Gallelli30
Estimated H-index: 30
+ 10 AuthorsMiriam Labonia1
Estimated H-index: 1
Chronic venous disease (CVD) and its most frightening complication, chronic venous ulceration (CVU), represent an important socioeconomic burden in the western world. Metalloproteinases have been identified in the pathogenesis of several vascular diseases such as venous problems. The aim of this study was to evaluate a broad range of metalloproteinases, such as matrix metalloproteinases (MMPs), ADAMs (a disintegrin and metalloproteinases) and ADAMTSs (a disintegrin and metalloproteinases with th...
10 Citations Source Cite
Published on Jan 5, 2017in BMJ 23.56
Thomas P. A. Debray19
Estimated H-index: 19
(Utrecht University),
Johanna A A G Damen3
Estimated H-index: 3
(Utrecht University)
+ 5 AuthorsKarel G. M. Moons77
Estimated H-index: 77
(Utrecht University)
Validation of prediction models is highly recommended and increasingly common in the literature. A systematic review of validation studies is therefore helpful, with meta-analysis needed to summarise the predictive performance of the model being validated across different settings and populations. This article provides guidance for researchers systematically reviewing and meta-analysing the existing evidence on a specific prediction model, discusses good practice when quantitatively summarising ...
32 Citations Source Cite
Published on Dec 15, 2016in Cochrane Database of Systematic Reviews 6.75
Maggie J Westby4
Estimated H-index: 4
(Manchester Academic Health Science Centre),
Gill Norman6
Estimated H-index: 6
(Manchester Academic Health Science Centre)
+ 2 AuthorsNicky Cullum48
Estimated H-index: 48
(Manchester Academic Health Science Centre)
Background Venous leg ulcers (VLUs) are open skin wounds on the lower leg that occur because of poor blood flow in the veins of the leg; leg ulcers can last from weeks to years, and are both painful and costly. Prevalence in the UK is about 2.9 cases per 10,000 people. First-line treatment for VLUs is compression therapy, but around 60% of people have unhealed ulcers after 12 weeks' treatment and about 40% after 24 weeks; therefore, there is scope for further improvement. Limited evidence sugges...
6 Citations Source Cite
Published on Oct 12, 2016in BMJ 23.56
Jonathan A C Sterne83
Estimated H-index: 83
(University of Bristol),
Miguel A. Hernán73
Estimated H-index: 73
(Harvard University)
+ 32 AuthorsIsabelle Boutron42
Estimated H-index: 42
(Paris Descartes University)
Non-randomised studies of the effects of interventions are critical to many areas of healthcare evaluation, but their results may be biased. It is therefore important to understand and appraise their strengths and weaknesses. We developed ROBINS-I (“Risk Of Bias In Non-randomised Studies - of Interventions”), a new tool for evaluating risk of bias in estimates of the comparative effectiveness (harm or benefit) of interventions from studies that did not use randomisation to allocate units (indivi...
725 Citations Source Cite
Published on Oct 1, 2016in Biochimica et Biophysica Acta 3.44
Daniela Ligi10
Estimated H-index: 10
,
Giovanni Mosti3
Estimated H-index: 3
+ 2 AuthorsFerdinando Mannello30
Estimated H-index: 30
Abstract Venous leg ulcers (VLU) are characterized by sustained proteolytic microenvironment impairing the healing process. Wound fluid (WF) reflect the biomolecular activities occurring within the wound area; however, it is unclear if WF from different healing phases have different proteolytic profiles and how VLU microenvironment affects the wound healing mechanisms. We investigated the proteolytic network of WF from distinct VLU phases, and in WF- and LPS-stimulated THP-1 monocytes treated wi...
16 Citations Source Cite
Published on Oct 1, 2016in Advances in wound care
SulemanLouise1
Estimated H-index: 1
Significance: Bacterial biofilms are considered to be responsible for over 80% of persistent infections, including chronic lung infections, osteomyelitis, periodontitis, endocarditis, and chronic wounds. Over 60% of chronic wounds are colonized with bacteria that reside within a biofilm. The exaggerated proteolytic environment of chronic wounds, more specifically elevated matrix metalloproteinases, is thought to be one of the possible reasons as to why chronic wounds fail to heal. However, the r...
12 Citations Source Cite
Published on Aug 1, 2016
Nicky Cullum48
Estimated H-index: 48
,
Hannah Buckley6
Estimated H-index: 6
+ 8 AuthorsMarta Soares21
Estimated H-index: 21
Background Complex wounds are those that heal by secondary intention and include lower-limb ulcers, pressure ulcers and some surgical wounds. The care of people with complex wounds is costly, with care mainly being delivered by community nurses. There is a lack of current, high-quality data regarding the numbers and types of people affected, care received and outcomes achieved. Objectives To (1) assess how high-quality data about complex wounds can be captured effectively for use in both service...
18 Citations Source Cite
Cited By1
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Published on Jan 23, 2019
Johanna A A G Damen3
Estimated H-index: 3
(Utrecht University),
Lotty Hooft28
Estimated H-index: 28
(Utrecht University)
Personalized, precision, and risk-based medicine are becoming increasingly important in medicine. These involve the use of information about the prognosis of a patient, to make individualized treatment decisions. This has led to an accumulating amount of literature available on prognosis studies. To summarize and evaluate this information overload, high-quality systematic reviews are essential, additionally helping us to facilitate interpretation and usability of prognosis study findings and to ...
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