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Protease activity as a prognostic factor for wound healing in venous leg ulcers
Published on Oct 30, 2017in Cochrane Database of Systematic Reviews 6.75
· DOI :10.1002/14651858.CD012841
Maggie J Westby4
Estimated H-index: 4
Jo C Dumville33
Estimated H-index: 33
+ 4 AuthorsRichard D Riley37
Estimated H-index: 37
(Keele University)
This is a protocol for a Cochrane Review (Prognosis). The objectives are as follows: To determine whether protease activity is an independent prognostic factor for the healing of venous leg ulcers.
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Published on Mar 1, 2001in Clinical Pharmacology & Therapeutics 6.54
Arthur J. Atkinson3
Estimated H-index: 3
(National Institutes of Health),
Wayne A. Colburn2
Estimated H-index: 2
+ 9 AuthorsBert Spilker2
Estimated H-index: 2
(Pharmaceutical Research and Manufacturers of America)
3,373 Citations Source Cite
Published on Aug 1, 2008in Minerva Cardioangiologica 0.57
Failla G1
Estimated H-index: 1
Campo S1
Estimated H-index: 1
+ 4 AuthorsDi Salvo M1
Estimated H-index: 1
Aim. The aim of this study was to compare the effect of cadexomer on reducing wound surface area of leg ulcers compared to that obtained in a group patients whose ulcers were treated by compression therapy. Methods. For each ulcer group, wound surface area was calculated at day 0 and after 28 days of treatment: this allowed to calculate the average wound surface area reduction, the percent reduction in wound size, as well as the weekly wound size reduction index. Results. In the cadexomer-treate...
1 Citations
Published on Dec 1, 2011in Ostomy Wound Management 0.99
Robert J. Snyder14
Estimated H-index: 14
Caroline E. Fife23
Estimated H-index: 23
+ 3 AuthorsWeir D1
Estimated H-index: 1
abstract Care of chronic and stalled wounds is hampered by the lack of diagnostic tools to help direct clinicians to specific treatments or diagnose specific conditions. Studies have shown a correlation between high protease levels and nonhealing wounds; a diagnostic protease test is under development. Seven wound care experts (two podiatrists, two vascular surgeons, a physician expert in hyperbaric oxygen therapy, a physical therapist with a specialty in home health, and a registered nurse) met...
22 Citations
Published on Sep 1, 1997in Laboratory Investigation 4.26
Sarah E. Herrick27
Estimated H-index: 27
Gillian S. Ashcroft38
Estimated H-index: 38
+ 3 AuthorsMark W. J. Ferguson57
Estimated H-index: 57
Chronic wound healing states are often associated with aging, and despite the increased number of aged patients with nonhealing wounds, controversy still exists concerning the effects of age on wound repair. Our previous work showed that in both venous ulcers in humans and acute wounds in aged animals, fibronectin, an early component in granulation tissue, is deficient compared to normal skin and acute wounds in healthy young animals, respectively. In the present study, we have determined the pr...
109 Citations
Published on Jan 1, 2004
Sittampalam Gs1
Estimated H-index: 1
Coussens Np1
Estimated H-index: 1
+ 17 AuthorsInglese J1
Estimated H-index: 1
2 Citations
Published on May 1, 1999in Vasa-european Journal of Vascular Medicine 1.21
A. A. Rogers1
Estimated H-index: 1
S. Burnett1
Estimated H-index: 1
+ 5 AuthorsW. Y. J. Chen1
Estimated H-index: 1
Background: Chronic wounds have been shown to exhibit elevated levels of several classes ofproteinases. Plasminogen activators (PAs) are proteinases which play a major role in the biological processes involved in wound healing and abnormalities in PAs may play a role in the pathology associated with chronic wounds. Here, we investigated the expression oftPA and uPA activities in chronic venous ulcer biopsies. Patients and methods : In 22 patients with chronic venous leg ulcers, punch biopsies we...
16 Citations Source Cite
Published on Aug 1, 2011in British Journal of Dermatology 6.13
H. Trøstrup1
Estimated H-index: 1
R. Lundquist1
Estimated H-index: 1
+ 4 AuthorsMagnus S. Ågren12
Estimated H-index: 12
Summary Background Knowledge on the underlying mechanisms for nonhealing chronic wounds is fragmentary. Objectives To increase our understanding of the pathogenesis, the relationship between healing ability and a large panel of proteins was studied using a specially designed wound-healing antibody-based microarray. Methods Wound fluid from nondiabetic patients with nonhealing venous leg ulcers was compared with that from patients with healing open granulating acute wounds. The high-throughput me...
23 Citations Source Cite
Published on Dec 7, 2007in British Journal of Dermatology 6.13
Melissa Laura Fernandez4
Estimated H-index: 4
(Queensland University of Technology),
James A. Broadbent7
Estimated H-index: 7
(Queensland University of Technology)
+ 2 AuthorsZee Upton30
Estimated H-index: 30
(Queensland University of Technology)
Summary Background Chronic venous leg ulcers are a significant cause of pain, immobility and decreased quality of life for patients with these wounds. In view of this, research efforts are focused on multiple factors in the wound environment to obtain information regarding the healing of ulcers. Objectives Chronic wound fluid (CWF), containing a complex mixture of proteins, is an important modulator of the wound environment, and therefore we hypothesized that these proteins may be indicators of ...
34 Citations Source Cite
Published on Jan 1, 2005in Wound Repair and Regeneration 2.95
Gunnel Ragnarson Tennvall11
Estimated H-index: 11
Jonas Hjelmgren6
Estimated H-index: 6
The aim of this study was to estimate costs of treating venous leg ulcers in Sweden and the United Kingdom during 1 year and to quantify costs in different health states, The costs of treating four different types of venous leg ulcers were estimated for 52 weeks by a stochastic health economic model, which simulated resource use data obtained from prospectively collected patient data, expert panels in the two countries, and published scientific. literature, The average cost of treating an ulcer ...
70 Citations Source Cite
Published on Aug 1, 2005in Journal of Investigative Dermatology 6.45
Stephen John Dalton2
Estimated H-index: 2
(University of Bristol),
David Mitchell9
Estimated H-index: 9
(Southmead Hospital)
+ 1 AuthorsJohn F. Tarlton24
Estimated H-index: 24
(University of Bristol)
Extracellular matrix (ECM) metabolism and homeostasis is sensitive to changes in oxygen tension manifest in ischemia. We hypothesize that in chronically ischemic limbs, abnormalities in uninjured skin, secondary to hypoxia, predispose to dermal breakdown. Paired biopsies of uninjured distal ischemic and proximal non-ischemic skin were harvested at below knee amputation from 14 patients with peripheral vascular disease following quantification of ischemia. Age- and site-matched controls were take...
27 Citations Source Cite
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