Fungal Cordycepin Biosynthesis Is Coupled with the Production of the Safeguard Molecule Pentostatin
Abstract
Cordycepin (COR) and pentostatin (PTN) are adenosine analogs with related bioactivity profiles as both mimic adenosine and can inhibit some of the processes that are adenosine dependent. Both COR and PTN are also natural products and were originally isolated from the fungus Cordyceps militaris and the bacterium Streptomyces antibioticus, respectively. Here, we report that not only is PTN produced by C. militaris but that biosynthesis of COR is...
Paper Details
Title
Fungal Cordycepin Biosynthesis Is Coupled with the Production of the Safeguard Molecule Pentostatin
Published Date
Dec 1, 2017
Journal
Volume
24
Issue
12
Pages
1479 - 1489.e4
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