Ultrasound verified inflammation and structural damage in patients with hereditary haemochromatosis-related arthropathy.

Published on Oct 24, 2017in Arthritis Research & Therapy4.148
· DOI :10.1186/S13075-017-1448-0
Christian Dejaco29
Estimated H-index: 29
(University of Graz),
Andreas Stadlmayr13
Estimated H-index: 13
+ 13 AuthorsJochen Zwerina58
Estimated H-index: 58
Background Chronic arthropathy occurs in approximately two thirds of patients with hereditary haemochromatosis (HH). The aim was to study inflammatory and structural lesions in patients with HH with (HH-A) and without arthropathy (HH-WA) using ultrasonography.
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  • Citations (3)
#1Anu R. Oke (QA: Queen Alexandra Hospital)H-Index: 1
#2Ernest Wong (QA: Queen Alexandra Hospital)H-Index: 3
Last. Steven Young-Min (QA: Queen Alexandra Hospital)H-Index: 11
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4 CitationsSource
#1L. MancarellaH-Index: 10
#2Olga AddimandaH-Index: 14
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Background: Ultrasound is one of the most promising candidates for the detection of inflammation and structural damage in hand osteoarthritis. Objective: To evaluate new advances of US as a diagnostic and prognostic tool in hand osteoarthritis assessment. Methods: We conducted a Medline on PubMed search for articles about “ultrasonography” and “hand OA” published between January 2012 and 15th April 2016, limiting our search to articles on human adults in English, excluding those involving system...
15 CitationsSource
#1Y Wu (UCSD: University of California, San Diego)H-Index: 1
#2K Chen (UCSD: University of California, San Diego)H-Index: 1
Last. Robert Terkeltaub (UCSD: University of California, San Diego)H-Index: 73
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Objectives Calcium pyrophosphate crystal deposition disease (CPPD) is common, yet prevalence and overall clinical impact remain unclear. Sensitivity and specificity of CPPD reference standards (conventional crystal analysis (CCA) and radiography (CR)) were meta-analysed by EULAR (published 2011). Since then, new diagnostic modalities are emerging. Hence, we updated 2009–2016 literature findings by systematic review and evidence grading, and assessed unmet needs. Methods We performed systematic s...
5 CitationsSource
Objective To examine whether ultrasound predicts radiographic hand osteoarthritis (OA) progression after 5 years. Methods We included 78 participants (71 women, mean (SD) age 67.8 (5.2) years) from the Oslo Hand OA cohort with ultrasound examination (gray-scale (GS) synovitis and power Doppler (PD) signals) at baseline and conventional radiographs and clinical examination at baseline and 5-year follow-up. Radiographic progression was defined as an increase in global OA according to the Kellgren–...
43 CitationsSource
#1Andrew McBride (UTAS: University of Tasmania)H-Index: 2
#2Hussain Ijaz Khan (UTAS: University of Tasmania)H-Index: 5
Last. Graeme Jones (UTAS: University of Tasmania)H-Index: 76
view all 10 authors...
Background The aim of this study was to examine whether cartilage volume as measured by MRI and radiographic osteoarthritis (OA) at baseline predict cartilage volume loss over ten years independent of each other and other structural co-pathologies.
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#1Peter Mandl (Medical University of Vienna)H-Index: 20
#2G. Supp (Medical University of Vienna)H-Index: 5
Last. Josef S. Smolen (Medical University of Vienna)H-Index: 115
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Objective To validate ultrasound (US) for measuring metacarpal cartilage thickness (MCT), by comparing it with anatomical measurement using cadaver specimens. To correlate US MCT with radiographic joint space narrowing (JSN) or width (JSW) in patients with rheumatoid arthritis (RA). Methods Bilateral metacarpophalangeal (MCP) joints of 35 consecutive outpatients, with recent hand X-rays, were included in the analysis. Metacarpal and phalangeal cartilage of MCP 2–5 was assessed bilaterally by US....
21 CitationsSource
#1Sébastien Ottaviani (Paris Diderot University)H-Index: 16
Last. Philippe DieudéH-Index: 39
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Objective. To compare the ability to detect calcium pyrophosphate (CPP) crystals deposition (CPPD) in knee cartilage by ultrasonography (US) and radiography. Methods. Patients with knee effusion were consecutively included and underwent radiography and US evaluation of knees. Diagnosis of CPPD was made by the identification of CPP crystals. Two blinded rheumatologists performed US assessment. Results. We included 51 patients (25 with CPPD). US revealed hyperechoic spots in all 25 patients with C...
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#1Anja Ficjan (University of Graz)H-Index: 7
#2Rusmir Husic (University of Graz)H-Index: 7
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Introduction This study was performed to develop ultrasound composite scores for the assessment of inflammatory and structural lesions in Psoriatic Arthritis (PsA).
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#1Rusmir Husic (University of Graz)H-Index: 7
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Objective To investigate the association between psoriatic arthritis (PsA)-specific clinical composite scores and ultrasound-verified pathology as well as comparison of clinical and ultrasound definitions of remission. Methods We performed a prospective study on 70 consecutive PsA patients. Clinical assessments included components of Disease Activity Index for Psoriatic Arthritis (DAPSA) and the Composite Psoriatic Disease Activity Index (CPDAI). Minimal disease activity (MDA) and the following ...
60 CitationsSource
#1Emma Husar-MemmerH-Index: 4
#2Andreas StadlmayrH-Index: 13
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Hereditary hemochromatosis is a frequent disease in Caucasian populations. It leads to progressive iron overload in a variety of organs. The most common cause is the C282Y homozygous mutation in the HFE gene. The classical triad of skin hyperpigmentation, diabetes, and liver cirrhosis is nowadays rare but musculoskeletal symptoms are common in HFE-related hemochromatosis. Typically the second and third metacarpophalangeal joints, and the wrist, hip, and ankle joints are affected. Clinical sympto...
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