Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors
Abstract
Whole-exome sequencing of cell-free DNA (cfDNA) could enable comprehensive profiling of tumors from blood but the genome-wide concordance between cfDNA and tumor biopsies is uncertain. Here we report ichorCNA, software that quantifies tumor content in cfDNA from 0.1× coverage whole-genome sequencing data without prior knowledge of tumor mutations. We apply ichorCNA to 1439 blood samples from 520 patients with metastatic prostate or breast...
Paper Details
Title
Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors
Published Date
Nov 6, 2017
Journal
Volume
8
Issue
1
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