The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels
Abstract
Summary null Mechanistic (or mammalian) target of rapamycin complex 1 (mTORC1) integrates signals from growth factors and nutrients to control biosynthetic processes, including protein, lipid, and nucleic acid synthesis. We find that the mTORC1 pathway is responsive to changes in purine nucleotides in a manner analogous to its sensing of amino acids. Depletion of cellular purines, but not pyrimidines, inhibits mTORC1, and restoration of...
Paper Details
Title
The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels
Published Date
Oct 31, 2017
Journal
Volume
21
Issue
5
Pages
1331 - 1346
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