IN GENETIC FRONTOTEMPORAL DEMENTIA, FUNCTIONAL NETWORK EFFICIENCY IS MAINTAINED UNTIL THE ONSET OF SYMPTOMS: EVIDENCE FOR FUNCTIONAL RESILIENCE TO STRUCTURAL CHANGE

Structural brain changes occur decades before symptom onset in genetic frontotemporal dementia (Rohrer et al., Lancet Neurol 2015; 4422: 1–10); though cognitive function can be well maintained presymptomatically. We assessed whether the integrity of functional networks would be maintained despite significant atrophy. 99 subjects from the Genetic Frontotemporal Dementia Initiative (GENFI) were recruited. Functional MRI was acquired at 11 sites at...