[P2-375]: THE EFFECT OF TAU BURDEN ON FUNCTIONAL CONNECTIVITY IN ALZHEIMER'S DISEASE AND PROGRESSIVE SUPRANUCLEAR PALSY

Alzheimer's Disease (AD) and Progressive Supranuclear Palsy (PSP) are neurodegenerative tauopathies. Although both are characterised by intracellular neurofibrillary hyperphosphorylated filamentous tau inclusions, the type and distribution of tau differs, together with their impact on brain connectivity and cognition. This multi-modal imaging study directly assessed the relationship between functional connectivity and tau burden to address the...