The Splicing Factor hnRNPA1 Regulates Alternate Splicing of the MYLK Gene

Volume: 58, Issue: 5, Pages: 604 - 613
Published: May 1, 2018
Abstract
Profound lung vascular permeability is a cardinal feature of acute respiratory distress syndrome (ARDS) and ventilator-induced lung injury (VILI), two syndromes known to centrally involve the nonmuscle isoform of myosin light chain kinase (nmMLCK) in vascular barrier dysregulation. Two main splice variants, nmMLCK1 and nmMLCK2, are well represented in human lung endothelial cells and encoded by MYLK, and they differ only in the presence of exon...
Paper Details
Title
The Splicing Factor hnRNPA1 Regulates Alternate Splicing of the MYLK Gene
Published Date
May 1, 2018
Volume
58
Issue
5
Pages
604 - 613
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