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Insula : neuropsychologie du cinquième lobe du cerveau

Published on Jul 1, 2017in Revue De Neuropsychologie
· DOI :10.1684/NRP.2017.0422
Olivier Boucher19
Estimated H-index: 19
,
Daphné Citherlet1
Estimated H-index: 1
+ 3 AuthorsDang Khoa Nguyen24
Estimated H-index: 24
Sources
Abstract
L’insula, consideree comme le cinquieme lobe du cerveau, est l’une des structures cerebrales les moins bien comprises et son role dans le fonctionnement neuropsychologique demeure enigmatique pour plusieurs. Au cours des dernieres annees, les etudes de stimulation electrocorticale, de lesion et de neuro-imagerie ont permis de mettre en lumiere plusieurs fonctions de cette structure cerebrale meconnue. Toutefois, ces differentes fonctions sont generalement abordees de facon isolee. Le present article de synthese vise a dresser le portrait des connaissances actuelles sur les multiples roles de l’insula chez l’humain. Apres une breve description de l’anatomie et de la connectivite de l’insula, son role dans les fonctions sensorimotrices, affectives et cognitives sera resume, et les subdivisions anatomofonctionnelles au sein meme du lobe insulaire seront decrites. Finalement, la contribution de l’insula a certaines psychopathologies sera abordee. Ce manuscrit offre aux neuropsychologues cliniciens et aux chercheurs en neuropsychologie un portrait global et exhaustif du role de l’insula dans le fonctionnement neuropsychologique.
  • References (24)
  • Citations (1)
References24
Newest
#1Karin B. Jensen (Université du Québec à Trois-Rivières)H-Index: 1
#1Karin B. JensenH-Index: 9
Last. Johan N. LundströmH-Index: 33
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AbstractIn response to recent publications from pain neuroimaging experiments, there has been a debate about the existence of a primary pain region in the brain. Yet, there are few meta-analyses providing assessments of the minimum cerebral denominators of pain. Here, we used a statistical meta-anal
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#1Costanza Papagno (University of Milan)H-Index: 41
#2Alberto Pisoni (University of Milan)H-Index: 12
Last. Lorenzo Bello (University of Milan)H-Index: 39
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Neuropsychological and neuroimaging studies yielded controversial results concerning the specific role of the insula in recognizing the facial expression of disgust. To verify whether the insula has a selective role in facial disgust processing, emotion recognition was studied in thirteen patients during intraoperative stimulation of the insula in awake surgery performed for removal of a glioma close to this structure. Direct electrical stimulation of the left insula produced a general decrease ...
24 CitationsSource
#1Jeremy Hogeveen (NU: Northwestern University)H-Index: 12
#2Geoffrey Bird (UCL: University College London)H-Index: 47
Last. Jordan Grafman (NU: Northwestern University)H-Index: 100
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Alexithymia is a subclinical condition characterized by impaired awareness of one's emotional states, which has profound effects on mental health and social interaction. Despite the clinical significance of this condition, the neurocognitive impairment(s) that lead to alexithymia remain unclear. Recent theoretical models suggest that impaired anterior insula (AI) functioning might be involved in alexithymia, but conclusive evidence for this hypothesis is lacking. We measured alexithymia levels i...
34 CitationsSource
#1Jelle R. DalenbergH-Index: 8
Last. G.J. Ter HorstH-Index: 20
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Abstract The primary gustatory area is located in the insular cortex. Although the insular cortex has been the topic of multiple parcellation studies, its functional specialization regarding taste processing received relatively little attention. Studies investigating the brain response to taste suggested that the insular cortex is involved in processing multiple characteristics of a taste stimulus, such as its quality, intensity, and pleasantness. In the current functional magnetic resonance stu...
31 CitationsSource
#1Olivier Boucher (UdeM: Université de Montréal)H-Index: 19
#2Isabelle Rouleau (UdeM: Université de Montréal)H-Index: 24
Last. Dang K. Nguyen (UdeM: Université de Montréal)H-Index: 10
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Abstract The insula has been implicated in social cognition and empathy in several neuroimaging paradigms. Impairments in social information processing, including specific deficits in disgust recognition, have been described following isolated insular damage, although the evidence remains limited to a few case studies. The present study examines social cognition and empathy in a group of fifteen patients for whom the insula was removed as part of their epilepsy surgery. These patients were compa...
35 CitationsSource
#1Madeleine S. Goodkind (Stanford University)H-Index: 6
#2Simon B. Eickhoff (HHU: University of Düsseldorf)H-Index: 92
Last. Amit Etkin (Stanford University)H-Index: 42
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Importance Psychiatric diagnoses are currently distinguished based on sets of specific symptoms. However, genetic and clinical analyses find similarities across a wide variety of diagnoses, suggesting that a common neurobiological substrate may exist across mental illness. Objective To conduct a meta-analysis of structural neuroimaging studies across multiple psychiatric diagnoses, followed by parallel analyses of 3 large-scale healthy participant data sets to help interpret structural findings ...
514 CitationsSource
#1P. zu Eulenburg (University of Mainz)H-Index: 3
#2Ulf Baumgärtner (Heidelberg University)H-Index: 27
Last. Marianne DieterichH-Index: 63
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Abstract The operculo-insular cortex has been termed the ‘homeostatic control center’ or ‘general magnitude estimator’ of the human mind. In this study, somatosensory, nociceptive and caloric vestibular stimuli were applied to reveal, whether there are mainly common, or possibly specific regions activated by one modality alone and whether lateralization effects, time pattern differences or influences of the aversive nature of the stimuli could be observed. Activation of the dorsal posterior insu...
43 CitationsSource
#1Bernhard Baier (University of Mainz)H-Index: 20
#2Julian ConradH-Index: 6
Last. Marianne DieterichH-Index: 63
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Background and Purpose—In previous imaging studies, the posterior insular cortex (IC) was identified as an essential part for vestibular otolith perception and considered as a core region of a human vestibular cortical network. However, it is still unknown whether lesions exclusively restricted to the posterior IC suffice to provoke signs of vestibular otolith dysfunction. Thus, present data aimed to test whether patients with lesions restricted to the IC showed vestibular otolith dysfunction. M...
26 CitationsSource
#1Kristine M. Knutson (NIH: National Institutes of Health)H-Index: 15
#2Shana Rakowsky (Georgetown University)H-Index: 6
Last. Jordan Grafman J (Rehabilitation Institute of Chicago)H-Index: 98
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Abstract Anxiety negatively affects quality of life and psychosocial functioning. Previous research has shown that anxiety symptoms in healthy individuals are associated with variations in the volume of brain regions, such as the amygdala, hippocampus, and the bed nucleus of the stria terminalis. Brain lesion data also suggests the hemisphere damaged may affect levels of anxiety. We studied a sample of 182 male Vietnam War veterans with penetrating brain injuries, using a semi-automated voxel-ba...
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#1Janina Seubert (Monell Chemical Senses Center)H-Index: 14
#2Jessica Freiherr (RWTH Aachen University)H-Index: 13
Last. Johan N. Lundström (KI: Karolinska Institutet)H-Index: 33
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Abstract Functional neuroimaging methods have been used extensively during the last decades to explore the neural substrates of olfactory processing. While a general consensus on the functional anatomy of olfactory cortex is beginning to emerge, the mechanisms behind the functions of individual processing nodes still remain debated. Further, it remains unclear to which extent divergent findings result from differences in methodological approaches. Using Activation Likelihood Estimation (ALE), th...
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Cited By1
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#1Vamsi Krishna Yerramneni (UdeM: Université de Montréal)
#2Alain Bouthillier (UdeM: Université de Montréal)H-Index: 20
Last. Dang Khoa Nguyen (UdeM: Université de Montréal)H-Index: 24
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Despite decades of research, the rate of epilepsy surgery failures in patients with drug refractory seizures remains important (30% for temporal and 50% for frontal lobe surgeries). Inaccurate localization or delimitation of the epileptic focus are the two most likely explanations and might be due to misleading clinical symptoms (as a result of local or propagated epileptic activity to other brain areas within the epileptic network) as well as limitations of standard localization tools. Indeed, ...
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