Concentration-dependent protein adsorption at the nano–bio interfaces of polymeric nanoparticles and serum proteins

Aim: A comprehensive understanding of nanoparticle (NP)-protein interaction (protein corona formation) is required. So far, many factors influencing this interaction have been investigated, like size and ζ potential. However, NPs exposure concentration has always been ignored. Herein, we aim to disclose the correlation of NPs exposure concentration with protein adsorption. Materials & methods: Four polymeric NPs systems possessing similar...