The small molecule AU14022 promotes colorectal cancer cell death via p53‐mediated G2/M‐phase arrest and mitochondria‐mediated apoptosis
Abstract
The p53 tumor suppressor plays critical roles in cell cycle regulation and apoptotic cell death, with its activation capable of sensitizing cancer cells to radiotherapy or chemotherapy. To identify small molecules that induce apoptosis via increased p53 transcriptional activity, we used a novel in‐house library containing 96 small‐molecule compounds. Using a cell‐based screening method with a p53‐responsive luciferase‐reporter assay system...
Paper Details
Title
The small molecule AU14022 promotes colorectal cancer cell death via p53‐mediated G2/M‐phase arrest and mitochondria‐mediated apoptosis
Published Date
Jan 15, 2018
Volume
233
Issue
6
Pages
4666 - 4676
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