Transcriptome profiling identifies genes/pathways associated with experimental resistance to paromomycin in Leishmania donovani

Volume: 7, Issue: 3, Pages: 370 - 377
Published: Dec 1, 2017
Abstract
Widespread resistance towards antimony and reports of relapses following miltefosine treatment has severely affected the management of visceral leishmaniasis (VL) in the Indian subcontinent. Paromomycin (PMM), an aminoglycoside antibiotic, has been licensed for VL treatment in India in 2007. Although its use is still restricted in the field, unraveling the molecular mechanism of resistance towards PMM is the key to preserve the drug. In this...
Paper Details
Title
Transcriptome profiling identifies genes/pathways associated with experimental resistance to paromomycin in Leishmania donovani
Published Date
Dec 1, 2017
Journal
Volume
7
Issue
3
Pages
370 - 377
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