Complement C5-inhibiting therapy for the thrombotic microangiopathies: accumulating evidence, but not a panacea
Abstract
Thrombotic microangiopathy (TMA), characterized by organ injury occurring consequent to severe endothelial damage, can manifest in a diverse range of diseases. In complement-mediated atypical haemolytic uraemic syndrome (aHUS) a primary defect in complement, such as a mutation or autoantibody leading to over activation of the alternative pathway, predisposes to the development of disease, usually following exposure to an environmental trigger....
Paper Details
Title
Complement C5-inhibiting therapy for the thrombotic microangiopathies: accumulating evidence, but not a panacea
Published Date
May 8, 2017
Journal
Volume
10
Issue
5
Pages
600 - 624
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