Cohesin Loss Eliminates All Loop Domains
Abstract
The human genome folds to create thousands of intervals, called “contact domains,” that exhibit enhanced contact frequency within themselves. “Loop domains” form because of tethering between two loci—almost always bound by CTCF and cohesin—lying on the same chromosome. “Compartment domains” form when genomic intervals with similar histone marks co-segregate. Here, we explore the effects of degrading cohesin. All loop domains are eliminated, but...
Paper Details
Title
Cohesin Loss Eliminates All Loop Domains
Published Date
Oct 1, 2017
Journal
Volume
171
Issue
2
Pages
305 - 320.e24
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