APOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA
Abstract
The APOBEC3 family of cytidine deaminases cause lethal hypermutation of retroviruses via deamination of newly reverse-transcribed viral DNA. Their ability to bind RNA is essential for virion infiltration and antiviral activity, yet the mechanisms of viral RNA recognition are unknown. By screening naturally occurring, polymorphic, non-human primate APOBEC3H variants for biological and crystallization properties, we obtained a 2.24-Å crystal...
Paper Details
Title
APOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA
Published Date
Oct 18, 2017
Journal
Volume
8
Issue
1
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