Enhancement of BLM-DNA2-Mediated Long-Range DNA End Resection by CtIP

Volume: 21, Issue: 2, Pages: 324 - 332
Published: Oct 1, 2017
Abstract
•CtIP enhances long-range resection by BLM-DNA2-RPA•CtIP interacts with and stimulates the activity of the BLM helicase•CtIP upregulates the endonuclease activity of DNA2•CtIP tetramerization is important for stimulation of long-range resection DNA double-strand break repair by homologous recombination entails the resection of DNA ends to reveal ssDNA tails, which are used to invade a homologous DNA template. CtIP and its yeast ortholog Sae2...
Paper Details
Title
Enhancement of BLM-DNA2-Mediated Long-Range DNA End Resection by CtIP
Published Date
Oct 1, 2017
Volume
21
Issue
2
Pages
324 - 332
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