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Insights into DDT resistance from the drosophila melanogaster genetic reference panel

Published on Nov 1, 2017in Genetics3.56
· DOI :10.1534/genetics.117.300310
Joshua M. Schmidt7
Estimated H-index: 7
(MPG: Max Planck Society),
Paul Battlay5
Estimated H-index: 5
(University of Melbourne)
+ 4 AuthorsCharles Robin18
Estimated H-index: 18
(University of Melbourne)
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Abstract
Insecticide resistance is considered a classic model of microevolution, where a strong selective agent is applied to a large natural population, resulting in a change in frequency of alleles that confer resistance. While many insecticide resistance variants have been characterized at the gene level, they are typically single genes of large effect identified in highly resistant pest species. In contrast, multiple variants have been implicated in DDT resistance in Drosophila melanogaster ; however, only the Cyp6g1 locus has previously been shown to be relevant to field populations. Here we use genome-wide association studies (GWAS) to identify DDT-associated polygenes and use selective sweep analyses to assess their adaptive significance. We identify and verify two candidate DDT resistance loci. A largely uncharacterized gene, CG10737 , has a function in muscles that ameliorates the effects of DDT, while a putative detoxifying P450, Cyp6w1 , shows compelling evidence of positive selection.
  • References (81)
  • Citations (10)
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References81
Newest
#1Helen Attrill (University of Cambridge)H-Index: 3
#2Kathleen Falls (Harvard University)H-Index: 9
Last.Steven J. Marygold (University of Cambridge)H-Index: 14
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#2Carson C. Chow (NIH: National Institutes of Health)H-Index: 43
Last.James J. Lee (UMN: University of Minnesota)H-Index: 66
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#1Kyle J. Gellatly (UMass: University of Massachusetts Amherst)H-Index: 3
#2Kyong Sup Yoon (SIU: Southern Illinois University Carbondale)H-Index: 24
Last.J. Marshall Clark (UMass: University of Massachusetts Amherst)H-Index: 30
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#1Justin B. Lack (UW: University of Wisconsin-Madison)H-Index: 14
#2Charis Cardeno (UC Davis: University of California, Davis)H-Index: 10
Last.John E. Pool (UW: University of Wisconsin-Madison)H-Index: 20
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#1Laura D. Steele (UIUC: University of Illinois at Urbana–Champaign)H-Index: 5
#2Brad S. Coates (Iowa State University)H-Index: 22
Last.Barry Robert Pittendrigh (UIUC: University of Illinois at Urbana–Champaign)H-Index: 25
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Cited By10
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#1Keon Mook Seong (MSU: Michigan State University)H-Index: 5
#2Brad S. Coates (ARS: Agricultural Research Service)H-Index: 22
Last.Barry Robert Pittendrigh (MSU: Michigan State University)H-Index: 25
view all 3 authors...
#1Wenyu Zhang (MPG: Max Planck Society)
#2Richard Guy Reeves (MPG: Max Planck Society)H-Index: 1
Last.Diethard Tautz (MPG: Max Planck Society)H-Index: 77
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#1Charles Robin (University of Melbourne)H-Index: 18
#2Paul Battlay (University of Melbourne)H-Index: 5
Last.Alexandre Fournier-Level (University of Melbourne)H-Index: 13
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#1Llewellyn Green (University of Melbourne)H-Index: 2
#2Paul Battlay (University of Melbourne)H-Index: 5
Last.Charles Robin (University of Melbourne)H-Index: 18
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View next paperSignatures of Insecticide Selection in the Genome of Drosophila melanogaster