Original paper
Genome editing reveals a role for OCT4 in human embryogenesis
Abstract
Despite their fundamental biological and clinical importance, the molecular mechanisms that regulate the first cell fate decisions in the human embryo are not well understood. Here we use CRISPR-Cas9-mediated genome editing to investigate the function of the pluripotency transcription factor OCT4 during human embryogenesis. We identified an efficient OCT4-targeting guide RNA using an inducible human embryonic stem cell-based system and...
Paper Details
Title
Genome editing reveals a role for OCT4 in human embryogenesis
Published Date
Sep 20, 2017
Journal
Volume
550
Issue
7674
Pages
67 - 73
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Notes
History