Mechanistic insight into the suppression of microglial ROS production by voltage-gated proton channels (VSOP/Hv1)
Abstract
Voltage-gated proton channels (VSOP/Hv1) reportedly promote reactive oxygen species (ROS) production in several immune cell types. However, we recently reported that primary microglia from VSOP/Hv1-deficient mice show higher ROS production than those from WT mice. Microglia may show a distinct activation status between WT and VSOP/Hv1-deficient cells, leading to a distinct level of ROS production between them. This is unlikely, however, because...
Paper Details
Title
Mechanistic insight into the suppression of microglial ROS production by voltage-gated proton channels (VSOP/Hv1)
Published Date
Nov 17, 2017
Journal
Volume
12
Issue
1
Pages
1 - 8
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