JMJD3 REGULATES THE EXPRESSION OF AUTOTAXIN

Autotaxin (ATX), which is encoded by the ENPP2 gene, is known to be a strong promoter of inflammation. The circulating level of ATX is increased in obese patients and promotes the development of calcific aortic valve disease. However, the regulation of ATX expression remains elusive. The objective of this study was to examine the molecular mechanism involved in the regulation of ATX expression. HEK293T cells were treated with 100 ng/ml of LPS...