DNA METHYLATION OF AN INTRONIC ENHANCER DYSREGULATES PHOSPHOLIPID PHOSPHATASE 3 AND PROMOTES OSTEOGENESIS IN THE AORTIC VALVE

Calcific aortic valve disease (CAVD) is characterized by the transition of valve interstitial cells (VICs) into osteoblast-like cells. Lysophosphatidic acid (LPA), which is produced in mineralized aortic valves (AVs), is a potent driver of osteogenic reprograming. LPA is degraded by the integral membrane protein phospholipid phosphatase 3, encoded by the PLPP3 gene. We examined the expression of PLPP3 in surgically explanted CAVD and in control...