Discovery and synthesis of novel Wogonin derivatives with potent antitumor activity in vitro
Abstract
Phenotypic screening of high quality compound library is one of the most effective strategy to obtain novel bioactive compounds. Recently, our group have constructed a Wogonin-scaffold library with substituents diversity and successfully obtained a series of potent compounds. Herein, we reported the synthesis of these compounds and evaluated the in vitro antitumor activity against a panel of human tumor cell lines. Most of them showed good...
Paper Details
Title
Discovery and synthesis of novel Wogonin derivatives with potent antitumor activity in vitro
Published Date
Nov 1, 2017
Volume
140
Pages
421 - 434
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