Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability

Genomic instability promotes evolution and heterogeneity of tumors. Unraveling its mechanistic basis is essential for the design of appropriate therapeutic strategies. In a previous study, we reported an unexpected oncogenic property of p21WAF1/Cip1, showing that its chronic expression in a p53-deficient environment causes genomic instability by deregulation of the replication licensing machinery.We now demonstrate that p21WAF1/Cip1 can further...