Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and Hypotension

The effect of an early resuscitation protocol on sepsis outcomes in developing countries remains unknown.To determine whether an early resuscitation protocol with administration of intravenous fluids, vasopressors, and blood transfusion decreases mortality among Zambian adults with sepsis and hypotension compared with usual care.Randomized clinical trial of 212 adults with sepsis (suspected infection plus ≥2 systemic inflammatory response...