Detoxification of ivermectin by ATP binding cassette transporter C4 and cytochrome P450 monooxygenase 6CJ1 in the human body louse, Pediculus humanus humanus

We previously observed that ivermectin‐induced detoxification genes, including ATP binding cassette transporter C4 ( PhABCC4 ) and cytochrome P450 6CJ1 ( CYP6CJ1 ) were identified from body lice following a brief exposure to a sublethal dose of ivermectin using a non‐invasive induction assay. In this current study, the functional properties of PhABCC4 and CYP6CJ1 were investigated after expression in either X. laevis oocytes or using a...