Prolonged intestinal transit and diarrhea in patients with an activating GUCY2C mutation

Increased intestinal hydration by activation of the epithelial enzyme linked receptor guanylate cyclase C (GC-C) is a pharmacological principle for treating constipation. Activating mutations in the GUCY2C gene encoding GC-C cause Familial GUCY2C diarrhea syndrome (FGDS) which has been diagnosed with severe dysmotility.To investigate gut motility and hormones before and after a meal in FGDS patients and compare with healthy controls (HC).Bristol...