Randomized, Double-Blind, Placebo- and Active Comparator–Controlled Crossover Study Evaluating the Abuse Potential of the Antiepileptic Drug Lacosamide in Healthy Recreational Drug Users

Purpose This phase 1, randomized, double-blind, placebo- and active comparator–controlled crossover study assessed the abuse potential of the antiepileptic drug, lacosamide. Methods After a qualification phase, 38 healthy, recreational central nervous system–depressant users were randomized to treatment sequences comprising single oral therapeutic (200 mg) and supratherapeutic (800 mg) doses of lacosamide, alprazolam (1.5 and 3 mg), and placebo....