Chromofungin Ameliorates the Progression of Colitis by Regulating Alternatively Activated Macrophages

Volume: 8
Published: Sep 15, 2017
Abstract
Ulcerative colitis (UC) is characterized by a functional dysregulation of alternatively activated macrophage (AAM) and intestinal epithelial cells (IECs) homeostasis. Chromogranin-A (CHGA) secreted by neuroendocrine cells is implicated in intestinal inflammation and immune dysregulation. CHGA undergoes proteolytic processing to generate CHGA-derived peptides. Chromofungin (CHR: CHGA47-66) is a short CHGA-derived peptide encoded by CHGA Exon-IV...
Paper Details
Title
Chromofungin Ameliorates the Progression of Colitis by Regulating Alternatively Activated Macrophages
Published Date
Sep 15, 2017
Volume
8
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