HMGB proteins and arthritis.
Abstract
The high-mobility group box (HMGB) family includes four members: HMGB1, 2, 3 and 4. HMGB proteins have two functions. In the nucleus, HMGB proteins bind to DNA in a DNA structure-dependent but nucleotide sequence-independent manner to function in chromatin remodeling. Extracellularly, HMGB proteins function as alarmins, which are endogenous molecules released upon tissue damage to activate the immune system. HMGB1 acts as a late mediator of...
Paper Details
Title
HMGB proteins and arthritis.
Published Date
Jan 1, 2018
Journal
Volume
31
Issue
1
Pages
1 - 9
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Notes
History