Antimicrobial Susceptibility Assessment of Clinical Clostridium difficile Isolates in Relation to CRISPR-Cas

CRISPR-Cas-associated adaptive immune system likely plays a role in the pathogenesis of Clostridium difficile infection and may alter resistance to commonly used antimicrobials. This study aims to assess the differences in antimicrobial susceptibility patterns based on the presence/absence of the CRISPR-Cas system in clinical C. difficile strains. In total, 60 clinical C. difficile isolates were included. The antibiotic sensitivity and...