Sigma 1 receptor regulates ERK activation and promotes survival of optic nerve head astrocytes
Abstract
The sigma 1 receptor (S1R) is a unique transmembrane protein that has been shown to regulate neuronal differentiation and cellular survival. It is expressed within several cell types throughout the nervous system and visceral organs, including neurons and glia within the eye. S1R ligands are therapeutic targets for diseases ranging from neurodegenerative conditions to neoplastic disorders. However, effects of S1R activation and inhibition within...
Paper Details
Title
Sigma 1 receptor regulates ERK activation and promotes survival of optic nerve head astrocytes
Published Date
Sep 12, 2017
Journal
Volume
12
Issue
9
Pages
e0184421 - e0184421
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