The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation

Nature64.80
Volume: 549, Issue: 7672, Pages: 351 - 356
Published: Sep 21, 2017
Abstract
Type 2 innate lymphoid cells (ILC2s) both contribute to mucosal homeostasis and initiate pathologic inflammation in allergic asthma. However, the signals that direct ILC2s to promote homeostasis versus inflammation are unclear. To identify such molecular cues, we profiled mouse lung-resident ILCs using single-cell RNA sequencing at steady state and after in vivo stimulation with the alarmin cytokines IL-25 and IL-33. ILC2s were transcriptionally...
Paper Details
Title
The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation
Published Date
Sep 21, 2017
Journal
Volume
549
Issue
7672
Pages
351 - 356
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