Glucagon-like peptide-1 affects human umbilical vein endothelial cells in high glucose by the PI3K/Akt/eNOS signaling pathway

Objectives To investigate the effects of glucagon-like peptide-1 (GLP-1) for the apoptosis of human umbilical vein endothelial cells (HUVECs) in high glucose and the related mechanisms. Material and methods HUVECs were cultured under different conditions for 48 h. The apoptosis rate of cells was detected by flow cytometry, the expression of p-Akt and p-eNOS was measured by Western blot, and the production of nitric oxide (NO) was detected by NO...