A Genetic Screen for Impaired Systemic RNAi Highlights the Crucial Role of DICER-LIKE 2
Abstract
Posttranscriptional gene silencing (PTGS) of transgenes involves abundant 21-nucleotide small interfering RNAs (siRNAs) and low-abundance 22-nucleotide siRNAs produced from double-stranded RNA (dsRNA) by DCL4 and DCL2, respectively. However, DCL2 facilitates the recruitment of RNA-DEPENDENT RNA POLYMERASE 6 (RDR6) to ARGONAUTE 1-derived cleavage products, resulting in more efficient amplification of secondary and transitive dsRNA and siRNAs....
Paper Details
Title
A Genetic Screen for Impaired Systemic RNAi Highlights the Crucial Role of DICER-LIKE 2
Published Date
Sep 19, 2017
Journal
Volume
175
Issue
3
Pages
1424 - 1437
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