Melatonin Improves Cognitive Deficits via Restoration of Cholinergic Dysfunction in a Mouse Model of Scopolamine-Induced Amnesia
Abstract
Melatonin is known to improve cognitive deficits, and its functions have been studied in various disease models, including Alzheimer’s disease. In this study, we investigated effects of melatonin on cognition and the cholinergic system of the septum and hippocampus in a mouse model of scopolamine-induced amnesia. Scopolamine (1 mg/kg) and melatonin (10 mg/kg) were administered intraperitoneally to mice for 2 and 4 weeks. The Morris water maze...
Paper Details
Title
Melatonin Improves Cognitive Deficits via Restoration of Cholinergic Dysfunction in a Mouse Model of Scopolamine-Induced Amnesia
Published Date
Sep 13, 2017
Journal
Volume
9
Issue
8
Pages
2016 - 2024
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