Shaping the niche in macrophages: Genetic diversity of the M. tuberculosis complex and its consequences for the infected host

Volume: 308, Issue: 1, Pages: 118 - 128
Published: Jan 1, 2018
Abstract
Pathogenic mycobacteria of the Mycobacterium tuberculosis complex (MTBC) have co-evolved with their individual hosts and are able to transform the hostile environment of the macrophage into a permissive cellular habitat. The impact of MTBC genetic variability has long been considered largely unimportant in TB pathogenesis. Members of the MTBC can now be distinguished into three major phylogenetic groups consisting of 7 phylogenetic lineages and...
Paper Details
Title
Shaping the niche in macrophages: Genetic diversity of the M. tuberculosis complex and its consequences for the infected host
Published Date
Jan 1, 2018
Volume
308
Issue
1
Pages
118 - 128
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