Propofol induces metabolic reprogramming and cell death in a mitochondrial electron transport chain-dependent manner

Pages: 181933
Published: Sep 10, 2017
Abstract
The intravenous anesthetic propofol (2,6-diisopropylphenol) has been used for the induction and maintenance of anesthesia in operating rooms and for sedation in intensive care units. Although there is no widely accepted definition of propofol infusion syndrome (PRIS), PRIS is defined as the development of metabolic acidosis, rhabdomyolysis, hyperkalemia, hepatomegaly, renal failure, arrhythmia, and progressive cardiac failure. In vitro evidence...
Paper Details
Title
Propofol induces metabolic reprogramming and cell death in a mitochondrial electron transport chain-dependent manner
Published Date
Sep 10, 2017
Journal
Pages
181933
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