LB1004 Probing the wound healing capacity of specialized skin

Sites of specialized skin, including the nipple exhibit efficient wound healing, with minimal scarring. The distinct epidermal and dermal features of these specialized skin regions are induced and maintained by signaling from local fibroblasts. Previous mRNA profiling of adult fibroblasts from a K14-PTHrP mouse, model of ectopic nipple development, suggested increased responsiveness to ovarian hormones, which in part reduced TGFβ-signaling that...