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CRISPR: Established Editor of Human Embryos?

Published on Sep 1, 2017in Cell Stem Cell21.46
· DOI :10.1016/j.stem.2017.08.007
Xiao-Jiang Li61
Estimated H-index: 61
(Emory University),
Zhuchi Tu7
Estimated H-index: 7
(JNU: Jinan University)
+ 1 AuthorsLi Shihua76
Estimated H-index: 76
(Emory University)
Abstract
Off-target effects and mosaicism are major concerns for applying CRISPR-Cas9 to correct genetic mutations. A recent article in Nature by Ma et al. (2017) uses an elegant CRISPR-Cas9 approach that repairs a genetic mutation in human embryos with negligible mosaicism and no off-target effects, bringing this editing tool closer to clinical application.
  • References (10)
  • Citations (1)
References10
Newest
#1Hong Ma (Oregon National Primate Research Center)H-Index: 27
#2Nuria Marti-Gutierrez (OHSU: Oregon Health & Science University)H-Index: 1
Last.Riffat Ahmed (OHSU: Oregon Health & Science University)H-Index: 10
view all 31 authors...
#1Lichun Tang (Protein Sciences)H-Index: 1
#2Yanting Zeng (Guangzhou Medical University)H-Index: 1
Last.Xiaowei Li (NU: Nanjing University)H-Index: 1
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#1Yongchang Chen (Kunming University of Science and Technology)H-Index: 11
#2Yinghui Zheng (CAS: Chinese Academy of Sciences)H-Index: 3
Last.Ruxiao Xing (CAS: Chinese Academy of Sciences)H-Index: 3
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#1Puping Liang (SYSU: Sun Yat-sen University)H-Index: 7
#2Yanwen Xu (SYSU: Sun Yat-sen University)H-Index: 14
Last.Yujing Li (SYSU: Sun Yat-sen University)H-Index: 10
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#1Alexandre Orthwein (Lunenfeld-Tanenbaum Research Institute)H-Index: 8
#2Amélie Fradet-Turcotte (Lunenfeld-Tanenbaum Research Institute)H-Index: 15
Last.Daniel Durocher (U of T: University of Toronto)H-Index: 53
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#1Evelyne Vanneste (Katholieke Universiteit Leuven)H-Index: 13
#2Thierry Voet (Katholieke Universiteit Leuven)H-Index: 31
Last.Frans Schuit (Katholieke Universiteit Leuven)H-Index: 59
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View next paperMosaicism in CRISPR/Cas9-mediated Genome editing.