The Impact of Heterozygous KCNK3 Mutations Associated With Pulmonary Arterial Hypertension on Channel Function and Pharmacological Recovery

Volume: 6, Issue: 9
Published: Sep 22, 2017
Abstract
Background Heterozygous loss of function mutations in the KCNK 3 gene cause hereditary pulmonary arterial hypertension ( PAH ). KCNK 3 encodes an acid‐sensitive potassium channel, which contributes to the resting potential of human pulmonary artery smooth muscle cells. KCNK 3 is widely expressed in the body, and dimerizes with other KCNK 3 subunits, or the closely related, acid‐sensitive KCNK 9 channel. Methods and Results We engineered...
Paper Details
Title
The Impact of Heterozygous KCNK3 Mutations Associated With Pulmonary Arterial Hypertension on Channel Function and Pharmacological Recovery
Published Date
Sep 22, 2017
Volume
6
Issue
9
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