Discovery of stimulation-responsive immune enhancers with CRISPR activation
Abstract
The majority of genetic variants associated with common human diseases map to enhancers, non-coding elements that shape cell-type-specific transcriptional programs and responses to extracellular cues. Systematic mapping of functional enhancers and their biological contexts is required to understand the mechanisms by which variation in non-coding genetic sequences contributes to disease. Functional enhancers can be mapped by genomic sequence...
Paper Details
Title
Discovery of stimulation-responsive immune enhancers with CRISPR activation
Published Date
Aug 30, 2017
Journal
Volume
549
Issue
7670
Pages
111 - 115
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Notes
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