Match!

Effects of a High-Fat Diet on Adipose Tissue CD8+ T Cells in Young vs. Adult Mice

Published on Dec 1, 2017in Inflammation2.94
· DOI :10.1007/s10753-017-0635-0
Lijun Dong1
Estimated H-index: 1
(Xinxiang Medical University),
Yao Zhang1
Estimated H-index: 1
(Xinxiang Medical University)
+ 3 AuthorsHui Wang11
Estimated H-index: 11
(Xinxiang Medical University)
Cite
Abstract
T cells are involved in chronic inflammation of adipose tissue in obese conditions. However, the impact of age on the adipose T cells remains unknown. In this study, we investigated T cells in the white adipose tissue of young and adult mice. Obesity was induced in the mice using a high-fat diet (HFD) for 14 weeks. The young mice were fed an HFD at 3 weeks old, and adult mice were fed the HFD at 12 weeks old. Relative to adult mice, the young mice gained less fat and exhibited better glucose tolerance. Their adipose tissue contained more CD8+ T cells and higher levels of pro-inflammatory cytokines. Young mice showed a larger increase in CD4+ T cells. The young and adult mice showed similar insulin tolerance. HFD reduced the colon muscle layer, which was more obvious in the young mice. These data suggested that young and adult mice exhibit different responses to an HFD in terms of adipose tissue, glucose tolerance, and the colon muscle layer. The increase in CD8+ T cells and CD4+ T cells, together with higher levels of pro-inflammatory cytokines, suggested elevated inflammation in the presence of less fat gain in the young mice, which was unexpected. The significance of this inflammation remains unknown. We propose that inflammation might inhibit energy storage in the adipose tissue to provide more energy to the lean body mass in favor of growth in the young mice. The present study provides another example of the beneficial effect of inflammation in physiological conditions.
  • References (63)
  • Citations (5)
Cite
References63
Newest
Published on Nov 8, 2016in Diabetes7.20
Brian F. Zamarron16
Estimated H-index: 16
(UM: University of Michigan),
Taleen Mergian6
Estimated H-index: 6
(UM: University of Michigan)
+ 7 AuthorsCarey N. Lumeng30
Estimated H-index: 30
(SCH: Soonchunhyang University)
Obesity causes dramatic proinflammatory changes in the adipose tissue immune environment, but relatively little is known regarding how this inflammation responds to weight loss (WL). To understand the mechanisms by which meta-inflammation resolves during WL, we examined adipose tissue leukocytes in mice after withdrawal of a high-fat diet. After 8 weeks of WL, mice achieved similar weights and glucose tolerance values as age-matched lean controls but showed abnormal insulin tolerance. Despite fa...
Published on Oct 1, 2016in Immunology and Cell Biology3.95
Lili Yu2
Estimated H-index: 2
(Xinxiang Medical University),
Guoyan Liu2
Estimated H-index: 2
(Xinxiang Medical University)
+ 2 AuthorsHui Wang11
Estimated H-index: 11
(Xinxiang Medical University)
Viral infections can disturb the functions of adipose tissues and thus result in metabolic diseases. Polyinosinic-polycytidylic acid (poly(I:C)), a synthetic analog of viral double-stranded RNA, induces innate antiviral responses by mimicking viral infection through the activation of pattern recognition receptors (PRRs) such as Toll-like receptor 3 (TLR3), retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5). Poly(I:C) also inhibits the differentiation of ...
Published on Dec 1, 2015in Nature Medicine30.64
Nicolas Suárez-Zamorano4
Estimated H-index: 4
,
Salvatore Fabbiano4
Estimated H-index: 4
+ 12 AuthorsStéphane Germain30
Estimated H-index: 30
Browning of white adipose tissue is induced by depletion of the microbiota, improving metabolic disease and reducing obesity.
Published on Jun 1, 2015in The FASEB Journal5.39
Injae Hwang2
Estimated H-index: 2
(SNU: Seoul National University),
Yoon Jeong Park30
Estimated H-index: 30
(SNU: Seoul National University)
+ 6 AuthorsJae Bum Kim39
Estimated H-index: 39
(SNU: Seoul National University)
Firmicutes and Bacteroidetes, 2 major phyla of gut microbiota, are involved in lipid and bile acid metabolism to maintain systemic energy homeostasis in host. Recently, accumulating evidence has suggested that dietary changes promptly induce the alteration of abundance of both Firmicutes and Bacteroidetes in obesity and its related metabolic diseases. Nevertheless, the metabolic roles of Firmicutes and Bacteroidetes on such disease states remain unclear. The aim of this study was to determine th...
Published on Apr 2, 2015in PLOS ONE2.78
Brandon D. Kayser4
Estimated H-index: 4
(SC: University of Southern California),
Michael I. Goran85
Estimated H-index: 85
(SC: University of Southern California),
Sebastien G. Bouret37
Estimated H-index: 37
(SC: University of Southern California)
Obesity causes white adipose tissue (WAT) inflammation and insulin resistance in some, but not all individuals. Here, we used a mouse model of early postnatal overfeeding to determine the role of neonatal nutrition in lifelong WAT inflammation and metabolic dysfunction. C57BL/6J mice were reared in small litters of 3 (SL) or normal litters of 7 pups (NL) and fed either regular chow or a 60% high fat diet (HFD) from 5 to 17 weeks. At weaning, SL mice did not develop WAT inflammation despite incre...
Published on Apr 1, 2015in Nature Immunology23.53
Felix M. Wensveen18
Estimated H-index: 18
(University of Rijeka),
Vedrana Jelenčić5
Estimated H-index: 5
(University of Rijeka)
+ 10 AuthorsF. Thomas Wunderlich19
Estimated H-index: 19
(MPG: Max Planck Society)
Visceral adipose tissue (VAT) inflammation drives obesity-induced insulin resistance. Polic and colleagues show that VAT NK cells sense obesity-induced adipose tissue stress and drive inflammation through the production of interferon-γ.
Published on Mar 1, 2015in Reviews in Endocrine & Metabolic Disorders5.52
Hui Wang11
Estimated H-index: 11
(Xinxiang Medical University),
Jianping Ye54
Estimated H-index: 54
(Louisiana State University System)
Inflammation regulates energy metabolism in both physiological and pathological conditions. Pro-inflammatory cytokines involves in energy regulation in several conditions, such as obesity, aging (calorie restriction), sports (exercise), and cancer (cachexia). Here, we introduce a view of integrative physiology to understand pro-inflammatory cytokines in the control of energy expenditure. In obesity, chronic inflammation is derived from energy surplus that induces adipose tissue expansion and adi...
Published on Mar 1, 2015in Psychoneuroendocrinology4.01
Amandine Lépinay3
Estimated H-index: 3
(University of Bordeaux),
Thomas Larrieu7
Estimated H-index: 7
(University of Bordeaux)
+ 10 AuthorsLionel Bretillon25
Estimated H-index: 25
(University of Burgundy)
Summary Epidemiological observations report an increase in fat consumption associated with low intake of n-3 relative to n-6 polyunsaturated fatty acids (PUFAs) in women of childbearing age. However, the impact of these maternal feeding habits on cognitive function in the offspring is unknown. This study aims to investigate the impact of early exposure to a high-fat diet (HFD) with an unbalanced n-6/n-3 PUFAs ratio on hippocampal function in adult rats. Furthermore, we explored the effects of pe...
Published on Jan 1, 2015in Journal of Leukocyte Biology4.01
Pooja Mehta4
Estimated H-index: 4
,
Alli M. Nuotio-Antar8
Estimated H-index: 8
(BCM: Baylor College of Medicine),
C. Wayne Smith76
Estimated H-index: 76
(BCM: Baylor College of Medicine)
γδ T cells are resident in AT and increase during diet-induced obesity. Their possible contribution to the inflammatory response that accompanies diet-induced obesity was investigated in mice after a 5 to 10 week milk HFD. The HFD resulted in significant increases in CD44hi, CD62Llo, and TNF-α+ γδ T cells in eAT of WT mice. Mice deficient in all γδ T cells (TCRδ−/−) or only Vγ4 and Vγ6 subsets (Vγ4/6−/−) were compared with WT mice with regard to proinflammatory cytokine production and macrophage...
Published on Oct 1, 2014in Cell Metabolism22.41
Mario Kratz19
Estimated H-index: 19
(UW: University of Washington),
Brittney R. Coats3
Estimated H-index: 3
(U of C: University of Chicago)
+ 13 AuthorsPeter Billing5
Estimated H-index: 5
Summary Adipose tissue macrophage (ATM)-driven inflammation plays a key role in insulin resistance; however, factors activating ATMs are poorly understood. Using a proteomics approach, we show that markers of classical activation are absent on ATMs from obese humans but are readily detectable on airway macrophages of patients with cystic fibrosis, a disease associated with chronic bacterial infection. Moreover, treating macrophages with glucose, insulin, and palmitate—conditions characteristic o...
Cited By5
Newest
Published on Feb 28, 2019in Mediators of Inflammation3.54
Sara J. Sidles (MUSC: Medical University of South Carolina), Ying Xiong4
Estimated H-index: 4
(MUSC: Medical University of South Carolina)
+ 1 AuthorsAmanda C. LaRue19
Estimated H-index: 19
(MUSC: Medical University of South Carolina)
Chronic inflammation is evident in the adipose tissue and periphery of patients with obesity, as well as mouse models of obesity. T cell subsets in obese adipose tissue are skewed towards Th1- and Th17-associated phenotypes and their secreted cytokines contribute to obesity-associated inflammation. Our lab recently identified a novel, myeloid-derived CD45
Zhe Wu2
Estimated H-index: 2
(PKU: Peking University),
Jiang Tan (PKU: Peking University)+ 6 AuthorsYulan Liu7
Estimated H-index: 7
(PKU: Peking University)
The mesenteric adipose tissue (MAT) lies between the gut and liver and plays a critical role in hepatic metabolic diseases. In the present study, we found that the MAT was prone to inflammation in ...
Published on Apr 1, 2018in Current Opinion in Immunology7.67
Ethan G. Aguilar6
Estimated H-index: 6
(UC Davis: University of California, Davis),
William J. Murphy84
Estimated H-index: 84
(UC Davis: University of California, Davis)
Obesity has been shown to increase risk for a number of different disorders, including cancer. In addition, obesity is also associated with immune dysfunction, which could contribute to its strong association with other comorbidities. Recently, the immune system has been found to be heavily regulated by changes in metabolism. In particular, T cells are able to respond to intrinsic metabolic regulatory mechanisms, as well as extrinsic factors such as the changes in metabolite availability. The dy...
Published on Jan 1, 2018in Oxidative Medicine and Cellular Longevity4.87
Ola Al-Assi1
Estimated H-index: 1
(AUB: American University of Beirut),
Rana Ghali3
Estimated H-index: 3
(AUB: American University of Beirut)
+ 5 AuthorsAhmed F. El-Yazbi15
Estimated H-index: 15
(Alexandria University)
Cardiac autonomic neuropathy (CAN) is an early cardiovascular complication of diabetes occurring before metabolic derangement is evident. The cause of CAN remains elusive and cannot be directly linked to hyperglycemia. Recent clinical data report cardioprotective effects of some antidiabetic drugs independent of their hypoglycemic action. Here, we used a rat model receiving limited daily increase in calories from fat (HC diet) to assess whether mild metabolic challenge led to CAN in absence of i...
Published on Nov 27, 2017in Nutrients4.17
Danyelle M. Liddle6
Estimated H-index: 6
,
Amber L. Hutchinson2
Estimated H-index: 2
+ 3 AuthorsJennifer M. Monk15
Estimated H-index: 15
Obesity is a global health concern with rising prevalence that increases the risk of developing other chronic diseases. A causal link connecting overnutrition, the development of obesity and obesity-associated co-morbidities is visceral adipose tissue (AT) dysfunction, characterized by changes in the cellularity of various immune cell populations, altered production of inflammatory adipokines that sustain a chronic state of low-grade inflammation and, ultimately, dysregulated AT metabolic functi...